Washington: Harvard researchers have discovered a hormone in fat cells that helps regulate how blood glucose is controlled and metabolised in the liver, paving way for new treatments for diabetes.Using experimental models and state-of-the-art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases. "Although it has long been recognised that a key event leading to development of type 2 diabetes is uncontrolled glucose production from the liver, underlying mechanisms have been elusive," said senior author Gokhan S Hotamisligil. "We now have identified aP2 as a novel hormone released from fat cells that controls this critical function," said Hotamisligil.
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