Washington: Researchers including an Indian have found that genes linked to chronic inflammation in asthma could be more active in obese people.First author Paresh Dandona, MD, PhD, SUNY Distinguished Professor and Chief of Endocrinology, Diabetes and Metabolism at the University at Buffalo, said that his team findings point the way to the management of asthma in the obese through simple weight reduction.The research involved two related studies: A comparative study between obese people and people of normal weights; and an experiment that looked at how various biological indicators - including the behavior of asthma-linked genes - changed when morbidly obese patients received gastric bypass surgery.In the comparative study, the scientists found that four genes associated with chronic inflammation in asthma were more active in obese and morbidly obese people, by more than 100 percent in some cases. The highest activity was found in the morbidly obese.This increased gene expression matters because it can cause white blood cells called mononuclear cells to produce far greater amounts of inflammatory factors like interleukin 4, LIGHT and lymphotoxin beta receptor which contribute to allergic inflammation and other abnormalities in the bronchial passages in asthma.
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