Washington: Scientists have discovered a mechanism that guides the exquisite wiring of neural circuits in a developing brain-gaining unprecedented insight into the faulty circuits that may lead to brain disorders ranging from autism to mental retardation.The researchers at Weill Cornell Medical College explained that faulty wiring occurs when RNA molecules embedded in a growing axon are not degraded after they give instructions that help steer the nerve cell. So, for example, the signal that tells the axon to turn-which should disappear after the turn is made-remains active, interfering with new signals meant to guide the axon in other directions.The scientists said that there might be a way to use this new knowledge to fix the circuits."Understanding the basis of brain miswiring can help scientists come up with new therapies and strategies to correct the problem," said the study`s senior author, Dr. Samie Jaffrey, a professor in the Department of Pharmacology.
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