Washington: Scientists are developing a new drug with a natural product secreted by a soil bacterium to treat tuberculosis.A team of scientists working in Switzerland has shown how pyridomycin, a natural antibiotic produced by the bacterium Dactylosporangium fulvum, works. This promising drug candidate is active against many of the drug-resistant types of the tuberculosis bacterium that no longer respond to treatment with the front-line drug isoniazid.“Nature and evolution have equipped some bacteria with potent defense mechanisms to protect them against other bugs that share their habitat. Screening natural products generated by these organisms is therefore a powerful way to find possible new drugs to fight infectious diseases,” Stewart Cole, lead author of the study, EMBO Member and a professor at the Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland, said.
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