Washington: Researchers have designed new compounds that could be the key to controlling hypertension and switching off the signalling pathways that lead to the deadly condition.The scientists from University of California, San Diego studied the properties of the peptide called catestatin that binds nicotinic acetylcholine receptors found in the nervous system, and developed a pharmacophore model of its active centers. They next screened a library of compounds for molecules that might match this 3D " fingerprint". The scientists then took their in-silico findings and applied them to lab experiments, uncovering compounds that successfully lowered hypertension."This approach demonstrates the effectiveness of rational design of novel drug candidates," lead author Igor F. Tsigelny, a research scientist with the university`s San Diego Supercomputer Center (SDSC), as well as the UC San Diego Moores Cancer Center and the Department of Neurosciences, said.
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