Washington: In a new study, scientists have tried to make new strategies to identify people who experienced intrauterine growth restriction (IUGR) and starvation during childhood at greatest risk of developing long term heart complications.The abstract study, conducted on Russians born during the Leningrad Siege in World War II, which was responsible for some of the greatest losses of civilian life in history, makes use of a unique population of people exposed to extreme starvation both as foetuses and during childhood.The cellular changes identified, investigators suggested, might be used to target treatments to children at greatest risk of developing heart complications.In a second study Spanish investigators elucidated structural changes occurring in the heart as a direct consequence of IUGR. Monitoring reversal of these changes, suggested the authors, might offer a “fast track” approach for testing effectiveness of new therapies.“Together, these innovative studies demonstrate the impact that basic research can have on the development of new approaches to heart treatments,” Sian Harding, Frontiers in CardioVascular Biology (FCVB) 2012 chairperson of the Core Scientific Committee, said.“New treatments preventing heart changes associated with poor nutrition would benefit those exposed to IUGR and also children who`ve experienced reduced calorie intakes, either due to food shortages or extreme dieting,” Harding said.
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