Washington: A surgeon from Indiana University School of Medicine is hoping to vanquish breast cancer that has metastasized to the brain by using glass, gold, nanotechnology and Greek mythology.Susan E. Clare, M.D., Ph.D., associate professor of surgery at the IU School of Medicine, is the initiating principal investigator for a 573,000-dollar Department of Defense grant that will allow her to explore a new approach to delivering therapy to brain metastases from primary breast cancer.As did the Greeks of old, Dr. Clare hopes to covertly deliver "warriors" to the enemy stronghold, in this case a metastatic brain tumor. Her research will explore using a cell from the body`s immune system to deliver chemotherapy directly to the brain metastases. The drug or other therapeutic is attached to the nanospheres, which are carried within the immune cell, much as soldiers were carried within the Trojan Horse. The immune cells travel in the bloodstream and release the drug when it has reached the tumor site.The two kinds of breast cancer that most commonly metastasize to the brain are HER2 positive and triple negative.
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