Washington: A new research from Western University has shed light on why some cancer cells don`t respond to chemotherapy, and identified a mechanism to rectify that.Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn`t kill the cancer cells the way it`s supposed to.Dr. Shawn Li, PhD, and his team at Western`s Schulich School of Medicine and Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 -a master regulator of cell death.The scientists found when Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53.
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