Washington: Researchers have discovered an abnormal amount of a protein called Prostaglandin D2 in the bald scalp of men with male pattern baldness.The discovery by researchers at Perelman School of Medicine at the University of Pennsylvania may lead directly to new treatments for the most common cause of hair loss in men.In both human and animal models, researchers found that a prostaglandin known as PGD2 and its derivative, 15-dPGJ2, inhibit hair growth.The PGD2-related inhibition occurred through a receptor called GPR44, which is a promising therapeutic target for androgenetic alopecia in both men and women with hair loss and thinning.Male pattern baldness strikes 8 of 10 men under 70 years old, and causes hair follicles to shrink and produce microscopic hairs, which grow for a shorter duration of time than normal follicles.Researchers took an unbiased approach when scanning for potential biological causes of baldness, looking in scalp tissue from balding and non-bald spots from men with male pattern baldness and then corroborating findings in mouse models.
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