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New paper-based diabetes test for developing countries

Washington: In a new study, scientists have reported the development of an inexpensive and easy-to-use urine test ideally suited for areas like rural India, China and other areas of the world where poverty limits the availability of health care and where the epidemics of Type 2 diabetes is looming.

Jan Lankelma and colleagues point out that monitoring glucose levels is important. Although diabetes test strips seem inexpensive, the cost can be prohibitive in areas where people must choose between that and the essentials of life, such as food and shelter.

In addition, current handheld diabetes monitoring devices measure glucose levels in blood, which requires a pin-prick to a finger — something that could deter patients from taking the measurements.

To address these challenges, the researchers built a new type of glucose monitor — one that detects glucose levels in urine (which is easy to obtain) and is made from inexpensive materials, such as paper.

The device consists of three electrodes, a buffer solution, a piece of paper (or nitrocellulose) and a plastic dish.

The sample is injected onto the paper with a slightly modified medical syringe, and the solution moves along the paper by gravity and capillary action.

An enzyme called glucose oxidase is already on the paper, and it reacts with glucose in the sample to produce hydrogen peroxide, which is detected by the electrodes.

The system can be built quickly, is inexpensive and produces results similar to those from a more expensive, commercially available clinical instrument.

The authors of the study state that the device could be used not only in a clinical lab, but it could also be further developed for applications as diverse as analyzing food quality and environmental monitoring.

The study has been published in the journal Analytical Chemistry.


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