Washington: A new study has found that CHD7 mutant neurons (a mutation in a gene) were fully rescued after a running exercise.The study also found that they were able to create functioning networks.That running causes a dramatic increase in neurogenesis in adults has been confirmed in animals and humans."We were extremely excited to see that the CHD7 deficiency in a cell can be bypassed via an unknown mechanism provoked by exercise involving running. Now, we are eagerly working to find the underlying mechanism," Dr. Haikun Liu`s lab at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) said.The neuroscientist believes this discovery will lead to a better understanding of the disease, possibly even pointing to a way to reactivate the CHD7 pathway and thus to attenuate CHARGE symptoms in human patients.CHD7 is also an important cancer-related gene; many different types of human cancers, including lung cancer, colon cancer and brain tumors exhibit mutations in the molecule.The mechanism identified here provides a clear explanation: A mutation in CHD7 leads to a blockage of differentiation in stem cells, which is a major cause of tumorigenesis.In addition, CHD7 has been identified as a high-risk gene in human autism, and many CHARGE patients are autistic. It seems that the gene is important in the regulation of many more physiological processes in the body.
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