A universal synthetic vaccine to beat flu?

Last Updated: Monday, February 21, 2011 - 00:00

Washington: Scientists have developed a nasal spray which they claim could be a synthetic universal vaccine for flu, using a genetic region that is common to all
strains of the virus.

An international team, led by University of Adelaide, has successfully trialled the synthetic universal flu vaccine in mice, the `Journal of General Virology` reported.

"Current flu vaccines rely on health authorities being able to predict what the forthcoming viral strain is going to be, and reformulating the vaccines each year accordingly. This is extremely time consuming, labour intensive and expensive,
and it`s something that a universal vaccine could overcome.

"A simple and totally synthetic universal vaccine --one that is not derived from an influenza virus and does not require annual reformulation -- would have clear advantages in health clinics to control and prevent the spread of flu," lead scientist Dr Darren Miller said.

For the research, the scientists used specific peptides delivered to the noses of mice. The peptides trigger an immune response to a tiny region of the flu virus that is present in all influenza A and B viruses, which effectively neutralises the virus.

The test vaccine provided mice with 100 per cent protection against a laboratory strain of virus (H3N2) and 20 per cent protection against a highly pathogenic virus (H5N1, or "bird flu"), which is consistent with the protection levels achieved with commercially available anti-influenza drugs.

"This is a positive response and one that shows promise for further testing both in laboratory and clinical settings," said Dr Miller.

According to him, while the universal vaccine could be given as an injection, using a nasal spray has a number of advantages: "It`s non-invasive and would be a preferred option for people afraid of needles. A nasal spray stimulates local immune responses at the natural site of virus entry.

"This vaccine would also reduce the allergy risk for many patients -- because current flu vaccines are grown in eggs, those who`re hypersensitive to eggs can`t be vaccinated.

Such a universal vaccine may also, of course, do away with the need for annual re-vaccinations, which is the situation many patients face today."

PTI



First Published: Monday, February 21, 2011 - 00:00

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