Abused kids more prone to chronic migraine

Washington: A new study has shown that kids who experience maltreatment such as emotional, physical and sexual abuse are more likely to experience frequent headaches, including chronic migraine, as adults.

Using data from the Adverse Childhood Experiences (ACE) Study of 17,337 adult members of the Kaiser Health Plan in San Diego, Gretchen E. Tietjen, of the University of Toledo College Of Medicine, and her team found that the number of ACEs showed a graded relationship to the likelihood of experiencing frequent headaches.

"We looked at eight ACEs -- emotional, physical, or sexual abuse, witnessing domestic violence, growing up with mental illness in the home, having household members who were incarcerated or were abusing drugs, and experiencing parental separation or divorce," said Dr. Tietjen.

"Each ACE increased the chance of frequent headache, and as the number of ACEs increased, so did the risk of frequent headache. This ``dose-response`` relationship`` suggests that ACEs may contribute to the development and frequency of severe headaches later in life," Dr. Tietjen added.

David Dodick, president of the AHS, said: "Earlier studies have linked childhood maltreatment to frequent headaches and migraine.”

"The biological underpinnings of this relationship should be a target of future research and clinicians should be aware of and evaluate for this important relationship in order to facilitate appropriate management strategies," he added.

The data has been presented at the American Headache Society``s 52nd Annual Scientific Meeting in Los Angeles this week.

Sleep deprivation linked to chronic migraine

Washington: Rapid eye movement (REM) sleep deprivation leads to changes in the levels of key proteins that facilitate events involved in the underlying pathology of migraine, a new study has found.

Paul L. Dunham and his team at Missouri State University``s Center for Biomedical & Life Sciences sought to understand the mechanisms by which sleep disturbance increases the risk of migraine and may even trigger migraine.

"Previous clinical data support a relationship between sleep quality and migraine, so we used an established model of sleep deprivation to measure levels of proteins that lower the activation threshold of peripheral and central nerves involved in pain transmission during migraine,” said Dr. Durham.

“We found that REM sleep deprivation caused increased expression of the proteins p38, PKA, and P2X3, which are known to play an important role in initiating and sustaining chronic pain," Dr. Durham added.

The study has been reported at the American Headache Society``s 52nd Annual Scientific Meeting in Los Angeles this week.


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