Zee Media Bureau
Washington: Want to live longer? Here is a good news for you, courtesy a pill.
In a breakthrough, scientists found that activating a protein called Sirtuin 1 (SIRT1) extends lifespan and delays the onset of age-related diseases in mice.
Scientists believe the study, which is published in the journal Cell Reports, could lead to a promising strategy in developing drugs that help to keep humans younger and healthier.
Sirtuin 1 or SIRT1 and its sister protein SIRT2 are known to play an essential roles in metabolism across a wide range of species.
Also, it has been found that drugs that increase SIRT1 activity slow the onset of ageing and delay age-associated diseases in several animal models.
The researchers led by Dr Rafael de Cabo, from the US National Institutes of Health, tested the effects of a small molecule that activates SIRT1, called SIRT1720, on the health and lifespan of mice.
The researchers found that SRT1720 significantly extended the average lifespan of mice by 8.8 percent.
They also found that mice fed with the molecule were also lighter and slimmer, with better muscle function and co-ordination throughout their lives.
Further studies showed that SRT1720 supplementation led to decreases in total cholesterol and LDL-cholesterol levels, which might help protect against heart disease, and improvements in insulin sensitivity, which could help prevent diabetes.
It has been observed that supplementation also had anti-inflammatory effects in various tissues. This is an important finding because low-grade chronic inflammation is thought to contribute to ageing and age-related diseases.
With Agency Inputs