Antibodies linked to infertility?

Last Updated: Friday, August 12, 2011 - 14:35

Washington: Scientists claim to have found antibodies which cause autoimmune diseases linked to female infertility.

An international team, led by the University of Western Australia, has found that the antibodies to glycoprotein zona pellucida 3 (ZP3) greatly depleted follicles within the ovary, causing complete infertility in mice.

The glycoprotein zona pellucida 3 is a vital component of ovarian follicles that is important for their development and enables fertilisation to occur.

The mice were given a genetically modified virus expressing the glycoprotein ZP3 which caused an immune response to the protein and the subsequent production of
antibodies.

Presence of the antibodies in the mice resulted in a fertility reduction within 14 days and complete infertility within 21 days.

Dr Megan Lloyd, who led the team, says these results show it is possible antibodies to ZP3 contribute to ovarian damage in humans.

"In humans there are a number of women who have infertility of unknown cause and a proportion of these women do have antibodies to ZP3. The importance of these antibodies is really difficult to determine because usually if you have infertility you`re probably quite away through the disease process already," Dr Lloyd said.

However, the scientists say that further research into the early stages of the auto immune disease is hard because diagnosis often occurs after the disease has done damage.

"We are hoping to look at the type of antibody that`s produced and what happens to that antibody whether it induces other parts of the immune system to act within the ovary," he
said.

PTI



First Published: Friday, August 12, 2011 - 14:35

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