Antibody-producing cells discovered in spleen
London: Researchers have discovered a type of cells in human spleen that are essential for the production of antibodies, paving way for development of new vaccines to fight meningitis and pneumonia.
Innate lymphoid cells were recently described by the scientific community and represent the first line of immunological defence on our body surfaces, which are constantly exposed to bacteria, such as the intestine or skin.
Now, for the first time their presence and function in human spleen has been described, said Dr Giuliana Magri, member of the research group of B Cell Biology at IMIM (Institut Hospital del Mar d'Investigacions Mediques) in Barcelona, and first author in the paper.
"We have discovered how these cells regulate the innate immune response of a subset of splenic B lymphocytes that are responsible to fight against encapsulated bacteria, causative agents of meningitis or pneumonia," said Magri.
"The current available vaccines against encapsulated bacteria confer only a limited protection in immunodeficient patients, and are too expensive to be implemented in developing countries.
"At the same time, we lack information on the underlying mechanisms that regulate B lymphocytes, which has been a major hurdle in the development of novel vaccine strategies," said Dr Andrea Cerutti, ICREA (Institucio Catalana de Recerca i Estudis Avancats) research professor and leader in the field of B lymphocyte biology.
"This makes the current discovery key in the design of novel more efficient and well-oriented therapies," Cerutti said.
The research involved in vitro studies with isolated cells from human spleen samples and in vivo studies performed with different mice models.
The work explored the function of the innate lymphoid cells in homeostasis, in short, in the absence of any illness, opening the door in the future to study the possible implication of innate lymphoid cells in diverse pathological processes both at the mucosal and systemic level, as well as deepening the understanding of autoimmune and immunodeficient diseases.
The study was published in the journal Nature Immunology.
More from India
More from World
More from Sports
More from Entertaiment
- Dr Subhash Chandra Show: Aspiring for more than what you have!
- Rajasthan: Gujjars revive reservation agitation, block rail track
- J Jayalalithaa sworn-in as Chief Minister of Tamil Nadu
- ISIS to buy first nuclear weapon from Pak?
- Mumbai: CCTV captures assailant with gun at Film City
- Mathura SSP receives death threat letter, message for PM Modi
- BJP now central pole of Indian politics: Arun Jaitley
- Maharashtra FDA sends Maggi noodles for lab testing
- Reservation issue: Police register case against Bainsla, 20 others
- Watch: Fast N Facts @ 7:30pm
- Zee Media exclusive chat with 'Welcome to Karachi' cast
- Haridwar: Hotel Radisson Blu sealed for polluting Ganga
- Zee Media exclusive interview with Haryana CM Manohar Lal Khattar
- Girl in Punjab's Pathankot quit studies for fear of eve-teasing
- Special: Furious over rising water crisis, people take to the streets
- ISIS close to buying nuclear weapon from Pakistan?
- Credibility of Prime Minister's Office restored by BJP, says Arun Jaitley
- IPL 2015 Final: Mumbai Indians vs Chennai Super Kings - Preview
- BJP's plan for one-year celebration: 200 big rallies, 5,000 public meetings
- IPL 2015 Final: MI vs CSK - As it happened...
- IPL 8 Final: We need to be at our best against Mumbai, says Michael Hussey
- Heatwave leaves 153 dead in Telangana, Andhra Pradesh
- Heatwave continues in North India; death toll in Andhra Pradesh, Telangana more than 400
- Heatwave kills 223 in AP, Telangana, Chandrababu Naidu announces compensation; Delhi records hottest day
- 'Tanu Weds Manu Returns' starts on a good note at the Box Office!
- Shocking! 7 veg food items that may actually be non veg
- CBSE 12th Result 2015 to be announced on Monday
- Say hello to 'nastiest' star ever
- CBSE.nic.in 12th XII Results 2015: CBSE Board (cbseresults.nic.in) Class 12th XII Exam Results 2015 to be announced on May 25
- Death threat to PM Narendra Modi ahead of Mathura rally sends police into tizzy