Antibody-producing cells discovered in spleen
London: Researchers have discovered a type of cells in human spleen that are essential for the production of antibodies, paving way for development of new vaccines to fight meningitis and pneumonia.
Innate lymphoid cells were recently described by the scientific community and represent the first line of immunological defence on our body surfaces, which are constantly exposed to bacteria, such as the intestine or skin.
Now, for the first time their presence and function in human spleen has been described, said Dr Giuliana Magri, member of the research group of B Cell Biology at IMIM (Institut Hospital del Mar d'Investigacions Mediques) in Barcelona, and first author in the paper.
"We have discovered how these cells regulate the innate immune response of a subset of splenic B lymphocytes that are responsible to fight against encapsulated bacteria, causative agents of meningitis or pneumonia," said Magri.
"The current available vaccines against encapsulated bacteria confer only a limited protection in immunodeficient patients, and are too expensive to be implemented in developing countries.
"At the same time, we lack information on the underlying mechanisms that regulate B lymphocytes, which has been a major hurdle in the development of novel vaccine strategies," said Dr Andrea Cerutti, ICREA (Institucio Catalana de Recerca i Estudis Avancats) research professor and leader in the field of B lymphocyte biology.
"This makes the current discovery key in the design of novel more efficient and well-oriented therapies," Cerutti said.
The research involved in vitro studies with isolated cells from human spleen samples and in vivo studies performed with different mice models.
The work explored the function of the innate lymphoid cells in homeostasis, in short, in the absence of any illness, opening the door in the future to study the possible implication of innate lymphoid cells in diverse pathological processes both at the mucosal and systemic level, as well as deepening the understanding of autoimmune and immunodeficient diseases.
The study was published in the journal Nature Immunology.
More from India
More from World
More from Sports
More from Entertaiment
- Indian Army conducts surgical strikes across LoC: Watch DGMO Lt Gen Ranbir Singh's PC
- Indian Army targets terror camps across LoC; Pak PM Sharif condemns
- 7 terror camps destroyed by Indian Army in surgical strikes
- Indian Army surgical strike: Pak rejects claim, says 2 soldiers killed
- Is it time for India to respond militarily to Pak terror instead of peace talks?
- SETBACK! Sedition case against 200 Congress workers for shouting 'Pakistan Zindabad' slogans during rally for Uri martyrs
- What is surgical strike and how it is conducted - MUST KNOW for every Indian
- SALUTE! Brave Indian army commandos give befitting reply to Pak-sponsored terrorists
- Surgical strikes across LoC in Pakistan were filmed, videos kept as proof
- US NSA Susan Rice calls Ajit Doval, says 'expect Pakistan to take action against terror’