Antibody `seeks cancer cure`

Last Updated: Friday, February 18, 2011 - 00:00

Melbourne: A joint team of Indian and Australian scientists claims to have achieved a breakthrough by creating an antibody which could be used for developing a
"medical smart bomb" that would help seek out and eradicate the root of cancer -- the stem cells.

The international project is a collaboration between Australia`s Deakin University and Indian Institute of Science in Bangalore along with Barwon Health`s Andrew Love Cancer Centre and Chem Genex Pharmaceuticals.

The team has, in fact, created the world`s first RNA aptamer, a chemical antibody that acts like a guided missile to seek out and bind only to cancer stem cells, the `Cancer
Science` journal reported.

The aptamer has the potential to deliver drugs directly to the stem cells (the root of cancer cells) and also to be used to develop a more effective cancer imaging system
for early detection of the disease, say the scientists.

The Director of Deakin Medical School`s Nanomedicine Program, Professor Wei Duan, said that the development of the aptamer had huge implications for the way cancer is detected and then treated.

Prof Duan said: "Despite technological and medical advances, the survival rates for many cancers remain poor, due partly to the inability to detect cancer early and then
provide targeted treatment.

"Current cancer treatments destroy the cells that form the bulk of the tumour, but are largely ineffective against the root of the cancer, the cancer stem cells. This suggests
that in order to provide a cure for cancer we must accurately detect and eliminate the cancer stem cells."

The aptamer is the first part of the "medical smart bomb" the scientists have been developing.

Prof Duan explained: "What we have created is the `guided missile` part of the `smart bomb`. The aptamer acts like a guided missile, targeting the tumour and binding to the
root of the cancer.

"The aim now is to combine the aptamer with the `bomb` (a microscopic fat particle) that can carry anti-cancer drugs or diagnostic imaging agents directly to the cancer stem cells
creating the ultimate medical smart bomb."

The scientists said the medical smart bomb opened up exciting possibilities for detection and treatment of cancer.

"The cancer stem cell-targeting missile and the smart bomb could revolutionise the way cancer is diagnosed. The minute size of the aptamer means it could locate cancer cells
in their very early stages.

"Attaching radioactive compounds to the aptamer could lead to the development of sensitive diagnostic scans for earlier detection, more accurate pinpointing of the location
of cancer, better prediction of the chance of cure and improved monitoring of the response to treatment.

"More accurate identification of the type of cancer present would lead to more personalised treatment that is more successful and cost-effective. This could ultimately lead to better cancer survival rates and greatly improved quality of life for patients," Prof Duan said.

PTI



First Published: Friday, February 18, 2011 - 00:00

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