Washington: Being skinny confers no advantage when it comes to the risk of dying suddenly from cardiac causes, say researchers.
In fact, boffins at the University of Rochester Medical Center found that non-obese heart failure patients – including overweight, normal and underweight patients – had a 76 percent increase in risk of sudden cardiac death compared to obese heart failure patients. Normal and underweight patients showed a startling 99 percent increase in risk for sudden cardiac death compared to obese patients.
The results have been presented at the American College of Cardiology Annual Scientific Session in Atlanta.
The study, by researchers from one of the world’s leading groups on sudden cardiac death, is the first to assess the relation between BMI and the risk of sudden cardiac death.
“This study is important because it not only answers questions regarding the risk of sudden cardiac death in different types of heart failure patients, but poses several new questions that need to be explored,” said corresponding study author Ilan Goldenberg, M.D., research associate professor of Medicine in the Cardiology Division. “Why do obese heart failure patients see a risk advantage? Why do normal weight patients have a significantly different risk profile than those who are slightly overweight? These are important questions that may have treatment implications in the future.”
To reach the conclusion, researchers at the University’s Heart Research Follow-Up Program examined the risk of sudden cardiac death in 1,231 patients who had suffered at least one prior heart attack and had been diagnosed with a low ejection fraction, a measurement of how much blood is pumped from the heart with each beat. Their analysis found that decreased BMI or body mass index was associated with a large increase in the risk of sudden cardiac death. These findings highlight the “obesity paradox,” a phenomenon long recognized by cardiologists that, once afflicted, obese heart failure patients fare better than their slimmer counterparts.
“When we started this study we were hoping the data would disprove the obesity paradox,” said Bonnie Choy, co-lead author and a second year medical student at the University’s School of Medicine and Dentistry. “Our study is the first to create and analyze subcategories within non-obese patients, looking at overweight, normal and underweight patients, but even with this advanced analysis we still the saw an inverse relationship between BMI and sudden cardiac death.”