Bioengineered blood vessel implanted into arm of patient with end-stage kidney disease
Washington: Doctors at Duke University Hospital created a bioengineered blood vessel and implanted it into the arm of a patient with end-stage kidney disease.
The procedure, the first US clinical trial to test the safety and effectiveness of the bioengineered blood vessel, is a milestone in the field of tissue engineering.
The new vein is an off-the-shelf, human cell-based product with no biological properties that would cause organ rejection.
Using technology developed at Duke and at a spin-off company it started called Humacyte, the vein is engineered by cultivating donated human cells on a tubular scaffold to form a vessel.
The vessel is then cleansed of the qualities that might trigger an immune response.
In pre-clinical tests, the veins have performed better than other synthetic and animal-based implants.
"It`s exciting to see something you`ve worked on for so long become a reality. We talk about translational technology - developing ideas from the laboratory to clinical practice - and this only happens where there is the multi-disciplinary support and collaboration to cultivate it," Jeffrey H. Lawson, M.D., PhD, a vascular surgeon and vascular biologist at Duke Medicine who helped develop the technology and performed the implantation, said.
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