Washington: Blocking a brain compound may have a magical effect in burning fat, even if you gorge yourself and avoid the gym, a study reveals.For instance, mice modified to limit production of the brain compound, an endocannabinoid called 2-AG, did not gain any weight, even after being fed high fat diets and becoming sluggish.Neither did they develop any signs of obesity and high blood pressure linked with cardiovascular disease and diabetes, the journal Cell Metabolism reported.Endocannabinoids are a group of lipids associated with appetite, pain-sensation, mood, and memory. All mammalian brains contain 2-AG."We discovered that these mice were resistant to obesity because they burned fat calories much more efficiently than normal mice do," said Daniele Piomelli, neuroscientist and pharmacology professor at the University of California, Irvine and colleagues.
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