Brain area’s possible role in drug addiction revealed
Last Updated: Tuesday, November 27, 2012, 16:41
  

Washington: Substance abuse researchers have concluded that an area of the brain called the orbitofrontal cortex is responsible for decisions made on the spur of the moment, but not those made based on prior experience or habit.

Scientists had previously believed that the area of the brain was responsible for both types of behaviour and decision-making. The distinction is critical to understanding the neurobiology of decision-making, particularly with regard to substance abuse.

Scientists have assumed that the orbitofrontal cortex plays a role in “value-based” decision-making, when a person compares options and weights consequences and rewards to choose best alternative.

The new study from substance abuse researchers at the University of Maryland School of Medicine and the National Institute on Drug Abuse (NIDA) showed that this area of the brain is involved in decision-making only when the value must be inferred or computed rapidly or hastily. If the value has been “cached” or pre-computed, like a habit, then the orbitofrontal cortex is not necessary.

The same is true for learning — if a person infers an outcome but it does not happen, the resulting error can drive learning. The study shows that the orbitofrontal cortex is necessary for the inferred value that is used for this type of learning.

“Our research showed that damage to the orbitofrontal cortex may decrease a person’s ability to use prior experience to make good decisions on the fly,” said lead author Joshua Jones, Ph.D., a postdoctoral researcher at the University of Maryland School of Medicine and a research scientist at NIDA, part of the National Institutes of Health.

“The person isn’t able to consider the whole continuum of the decision — the mind’s map of how choices play out further down the road. Instead, the person is going to regress to habitual behavior, gravitating toward the choice that provides the most value in its immediate reward,” the researcher stated.

The study enhances scientists’ understanding of how the brain works in healthy and unhealthy individuals, according to the researchers.

“This discovery has general implications in understanding how the brain processes information to help us make good decisions and to learn from our mistakes,” said senior author Geoffrey Schoenbaum, M.D., Ph.D., adjunct professor at the University of Maryland School of Medicine and senior investigator and chief of the Cellular Neurobiology Research Branch at NIDA.

“Understanding more about the orbitofrontal cortex also is important for understanding disorders such as addiction that seem to involve maladaptive decision-making and learning. Cocaine in particular seems to have long-lasting effects on the orbitofrontal cortex. One aspect of this work, which we are pursuing, is that perhaps some of the problems that characterize addiction are the result of drug-induced changes in this area of the brain,” he noted.

The scientists are continuing their research, examining the specific coding of the neurons in the orbitofrontal cortex during this process, as well as the effects that drugs of abuse have upon this area of the brain.

“Drug addiction is marked by severe deficits in judgment and bad decision-making on the part of the addict. We believe that drugs, particularly cocaine, affect the orbitofrontal cortex. They coerce the system and hijack decision-making,” said Dr. Jones.

The study was published online in the journal Science.

ANI


First Published: Tuesday, November 27, 2012, 16:41



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