Washington: Scientists claim to haveverified the protein that has long been suspected of being themaster switch allowing brains to function. A team, led by Yeon-Kyun Shin at Iowa State Universityin the US, has shown that the protein called synaptotagmin1 isthe sole trigger for the release of neurotransmitters in thebrain, the `Science` journal reported.
Syt1 senses, at 10 ppm of calcium, and tells the SNAREcomplex to open pore to allow movement of neurotransmitters.Brain activity occurs when neurotransmitters move into fusionpore. "We are showing that this Syt1 senses the calcium at10 ppm, and sends the signal to the SNARE complex to open thefusion pore. That is the process that we are showing rightnow," Shin said. The team was able to pinpoint the protein using anew technique called single vesicle fusion method. Using thismethod, they were able to create and monitor a single fusionevent. "We are quite excited that for the first timewe are showing that Syt1 is really what triggers the signalin the brain. This is a really important thing in terms ofneurosciences. This is the heart of the molecular part of thebrain function," Shin said. PTI
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