Brain’s nicotine receptors treat schizophrenia
Washington: Scientists have suggested that nicotine receptors of the brain, which are important to smokers trying to quit tobacco, also play an important role in social interaction and the ability to choose between competing motivations.
Specifically, scientists from France showed that the nicotinic receptors in the prefrontal cortex are essential for social interaction in mice and that this area of the brain is necessary for adapted and balanced social interactions to occur.
This new knowledge could one day lead to novel treatments for ADHD, schizophrenia, and depression, among other illnesses.
“One of the main aims would be to understand and help people to make good decisions for themselves (and for others) and to maintain, during old age, such abilities in the social domain as well as in other aspects of our lives,” Sylvie Granon, a researcher from the Universite Paris Sud XI and CNRS UMR 8620, Centre de Neurosciences Paris-Sud, Orsay, France, said.
To make this discovery, Granon and colleagues introduced mice into an open space and tested their will to interact with other mice of the same sex or to explore a novel place.
The respective times spent for either social contact or novelty exploration were measured and quantitatively evaluated.
Researchers then removed the prefrontal cortex in otherwise normal mice, which resulted in mice with significant social deficits.
Those genetically modified to lack the nicotinic receptor gene for a widespread subunit called beta2 subtype, seemed to favor social contact rather than the investigation of a novel environment.
When the beta2 nicotinic receptor in the brain was re-expressed, a normal balance between social contact and novelty seeking was restored.
The study was published in the FASEB Journal.
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