Washington: Researchers have suggested that a cancer drug that works by inhibiting the growth of blood vessels might also help reduce fat.It has been long known that cancerous tumors grow collections of abnormal blood cells, the fuel that feeds this disease and keeps it growing. Now, new evidence in an animal model suggests that blood vessels in the fat tissue of obese individuals could provide the same purpose-and could provide the key to a new way for people to lose weight. When researchers Jian-Wei Gu, Kristina L. Makey, Edmund Chinchar, Carissa Howie, and Lucio Miele, all from the University of Mississippi Medical Center, gave obese mice the cancer drug, known as Sunitinib, these mice lost about 70 percent of their fat mass.More than a decade ago, Judah Folkman of Harvard Medical School, whose primary research focus was the growth of blood vessels in cancerous tumors, discovered that fat tissue in mice could be regulated by angiogenesis inhibitors-drugs that restrain the growth of blood vessels. However, Gu explained, Folkman never pursued this line of research further before his death in 2008.
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