Washington: In a new study, researchers have suggested that JQ1 can reactivate latent HIV and potently suppress inflammation, making it effective against HIV and other inflammatory conditions.
Breakthrough drugs have made it possible for people to live with HIV longer than ever before, but more work must be done to actually cure the disease and one of the challenges researchers face involves fully eradicating the virus when it is latent in the body.
“This drug may be useful as adjunctive therapy in efforts to purge latent HIV reservoirs to eradicate infection,” Monty A. Montano, principal investigator from the Section of Infectious Diseases at Boston University Medical Campus, in Boston, Mass, said.
“This drug functions synergistically with other HIV purging agents,” he said.
To make this discovery, scientists used cell lines that contained latent HIV, as well as cells from patients who were on potent antiretroviral therapy with no detectable virus in their blood.
Researchers then added JQ1 to latently infected cells, at physiologic concentrations, and observed potent reactivation of latent HIV. The researchers also observed potent suppression of inflammatory genes in genome-wide expression studies using the same cells. JQ1 reactivation of latent HIV may make it vulnerable to current therapies.
“One thing that’s been made clear by the decades of HIV research is that there is no magic bullet for curing this disease,” John Wherry, Deputy Editor of the Journal of Leukocyte Biology, said.
“Rather, the progress that’s been made has been a series of incremental steps that often build on other previously developed therapies. The hope is that the ability of JQ1 to make latent HIV ‘visible’ to other HIV drugs described in this report will be another cog in the gearwheel of an HIV cure,” he added.
The study has been published in the Journal of Leukocyte Biology.