Washington: Researchers have found a cell in the kidney that could be key to understanding why diabetes leads to kidney failure.Diabetes related kidney disease has previously been thought to be mainly due to the high levels of sugar in the blood damaging the small blood vessels in the kidney.
To find out whether insulin signalling in podocytes affects kidney function the researchers used mice that genetically had the insulin receptor removed from their podocytes, thereby making only this cell unresponsive to insulin in the body.They found that the mice developed kidney disease with many similarities to that seen in diabetic patients, except that the mice all had normal blood sugar levels.The findings were published in Cell Metabolism. ANI
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