London: Scientists have managed to grow a recently discovered species of human rhinovirus (HRV), the most frequent cause of the common cold, in culture, on sinus tissue removed during surgery.Researchers at the University of Wisconsin-Madison found that the virus, which is associated with up to half of all HRV infections in children, has reproductive properties that differ from those of other members of the HRV family.The report sheds light on HRV-C, a new member of the HRV family that also includes the well known HRV-A and HRV-B.
"We also found that HRV-C does not attach to the two receptors that HRV-A and HRV-B use," Bochkov said."HRV-C uses a distinct, yet unknown, receptor that is absent or under-expressed in many cell lines," he stated.HRV-C also responded differently to antibodies that block receptor binding."Antibodies that normally keep HRV-A and HRV-B from binding to their receptors did not prevent HRV-C from binding to them," Bochkov revealed.Gern said the findings suggest that new approaches are needed to treat HRV-C."Previous drug candidates for the common cold were tested only against HRV-A and HRV-B. For more effective medications, we need to also target HRV-C," he stated.Bochkov will continue to use the organ culture system to study details of HRV-C biology."It`s now clear that these viruses have unique growth requirements," he added.The findings have been reported in Nature Medicine on April 11. ANI
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