Washington: A recent study has revealed that women who have a specific type of antibody that interferes with blood vessel function are at risk for adverse pregnancy outcomes and that other antibodies in the same family thought to cause pregnancy complications do not put women at risk.The study was led by Hospital for Special Surgery researchers.The researchers say that many doctors may be unnecessarily treating some pregnant women who have antiphospholipid antibodies (aPLs) with anticoagulants, such as expensive heparin injections, which can cause bleeding and bone loss.“This paper identifies people who are at risk for pregnancy loss and, more importantly, those who are not at risk and who therefore do not need to be treated,” said Michael Lockshin, M.D., director, Barbara Volcker Center for Women and Rheumatic Disease, and co-director, Mary Kirkland Center for Lupus Research at Hospital for Special Surgery (HSS), New York City, and lead author of the study.Antiphospholipid antibodies interfere with phospholipids, a type of fat found in all living cells and cell membranes, including blood cells and the lining of blood vessels. Patients with these antibodies are at risk for blood clots, stroke, and pregnancy complications, but some patients with these antibodies can be completely healthy.“Phospholipids are highly exposed in the placenta, and as a result antiphospholipid antibodies concentrate there. When antibodies are deposited in a person`s tissues, inflammation is initiated leading to organ damage,” said Jane Salmon, M.D., the study``s senior author and Collette Kean Research Chair and co-director, Mary Kirkland Center for Lupus Research at HSS.And this is a mechanism for pregnancy complications.
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