DEET breakthrough could revolutionize global battle against malaria

Washington: Researchers including an Indian-origin have known that insects are repelled by N,N-diethyl-m-toluamide, also known as DEET, but which olfactory receptors insects used to sense it had eluded scientists for long.

Now researchers at the University of California, Riverside have identified the DEET-detecting olfactory receptors that cause the repellency.

Further, the team of researchers has identified three safe compounds that mimic DEET and could one day be used to prevent the transmission of deadly vector-borne diseases such as malaria, dengue, West Nile virus, and yellow fever.

Lead researcher Anandasankar Ray, an associate professor of entomology, said that until now, no one had a clue about which olfactory receptor insects used to avoid DEET and without the receptors, it is impossible to apply modern technology to design new repellents to improve upon DEET.

The method Ray's team used to identify the receptors examined in an unbiased fashion all the sensory neurons in the insect, which was the key to successfully finding them. In their experiments, the researchers used the genetic model system Drosophila melanogaster (fruit fly) that was genetically engineered in such a way that neurons activated by DEET glowed fluorescent green.

The researchers thus found the receptors, called Ir40a receptors, lining the inside of a poorly studied region of the antenna called the sacculus.

The study has been published online in journal Nature.