Washington: Rising temperature induces key changes in the dengue virus when it enters its human host, researchers have discovered.The findings represent a new approach for designing vaccines against the aggressive mosquito-borne pathogen.The researchers, led by Michael G. Rossmann, Hanley Distinguished Professor of Biological Sciences, found that the dengue virus particles swell slightly and take on a bumpy appearance when heated to human body temperature, exposing "epitopes," or regions where antibodies could attach to neutralize the virus.The discovery is significant because it could help to explain why vaccines against dengue have been ineffective, said Michael G. Rossmann, Hanley Distinguished Professor of Biological Sciences at Purdue University.
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