Diabetes drug pioglitazone may up bladder cancer risk
London: Pioglitazone - a drug used to treat type 2 diabetes – appears to increase risk of developing bladder cancer, a new study has warned.
The results show that more than two years daily exposure to pioglitazone doubles the risk of bladder cancer.
But the researchers noted that in absolute terms, the risks are low – up to 137 extra cases per 100,000 person years.
No increased risk was seen for a similar drug (rosiglitazone).
Pioglitazone and rosiglitazone belong to a class of drugs called thiazolidinediones that help to control blood sugar levels in patients with type 2 diabetes. Both drugs are known to increase the risk of heart failure but, after carrying out a safety review, the European Medicines Agency decided to keep pioglitazone on the market.
However, there is now some evidence suggesting that pioglitazone may be associated with an increased risk of bladder cancer.
So a team of researchers based in Canada set out to determine if the use of pioglitazone was associated with an increased risk of bladder cancer in people with type 2 diabetes.
Using data from the General Practice Research Database (GPRD), which contains anonymised patient records from more than 600 UK general practices, they studied 115,727 patients newly treated with diabetes drugs from 1988 to 2009. Cases of bladder cancer were identified and matched to up to 20 healthy control patients.
Results showed that 470 patients were diagnosed with bladder cancer during the average 4.6 years of follow-up (a rate of 89 per 100,000 person years). The rate of bladder cancer in the general UK population aged at least 65 years is 73 per 100,000 person years.
The analysis involved 376 cases, matched to 6,699 controls.
If patients had ever taken pioglitazone they were at an 83 percent increased risk of bladder cancer. This corresponds to 74 per 100,000 person years. This increased to 88 per 100,000 person years for patients who had taken the drug for two years or more and increased further to 137 per 100,000 years for patients who had taken 28,000mg or more.
These findings remained consistent in several further analyses designed to check the results.
The researchers concluded that their results “provide evidence that pioglitazone is associated with an increased risk of bladder cancer, whereas no increased risk was observed with the thiazolidinedione rosiglitazone.”
They suggest that such associations may have been underestimated in previous observational studies and say doctors, patients and regulatory agencies “should be aware of this association when assessing the overall risks and benefits of this therapy.”
The finding has been published on bmj.com.
More from India
More from World
More from Sports
More from Entertaiment
- Street food in Delhi contains high levels of faecal matter
- Meet 92-year-old Phyllis Sues who dances toTango
- Watch: ISIS prisoner digging his own grave
- 50 percent refund on Tatkal ticket cancellation
- Priyanka, Ranveer talk about their film 'Dil Dhadakne Do'
- Erstwhile Mysuru kingdom gets new king
- UP: Govt to distribute free sanitary napkins to all girls in school
- Former Bihar CM Jitan Ram Manjhi meets PM Modi
- Delhi HC turns down plea challenging LG Jung's authority
- DNA: Pentagon report says Beijing accelerates land reclamation in South China Sea
- IIT Madras bans Dalit students forum for 'criticising' PM Modi
- Radioactive nuclear medicine leak detected at Delhi's IGI Airport
- DNA: Blow to Kejriwal, Delhi High Court backs LG
- IIT Madras row: Smriti Irani hits back, challenges Rahul Gandhi to a debate
- DNA: World soccer rocked by Swiss arrests of FIFA officials for graft
- Rahul Gandhi takes another dig at NDA govt, says Manmohan gave lessons on economy to PM Modi
- Delhi HC backs LG, turns down plea challenging Jung's authority
- WB Class 12 (HS) Result 2015 declared on wbresults.nic.in, wbchse.nic.in
- No radioactive leak at IGI airport, say AERB and Delhi govt
- WBCHSE (wbchse.nic.in & wbresults.nic.in): West Bengal Class 12th Result to be declared on May 29
- Log on to wbresults.nic.in, wbchse.nic.in for WB Class 12 (HS) Result 2015 WBCHSE
- WBCHSE (wbchse.nic.in & wbresults.nic.in): West Bengal Class 12th Result 2015 to be announced shortly
- Twitter war over IIT Madras row: Smriti Irani challenges Rahul Gandhi to debate over any issue, anywhere
- Dangerous levels of toxins in Delhi's air as heat and dust intensify
- Check out: Salman Khan goes across the border in 'Bajrangi Bhaijaan' teaser
- Top 5 places to eat in Delhi University's campuses
- Baal nahi ball ko dekho: Sachin Tendulkar's tip to tackle Lasith Malinga
- Waiting for Jaypee to come back to me on Indian GP's return in 2016: Bernie Ecclestone
- WBCHSE (wbchse.nic.in & wbresults.nic.in): West Bengal Class 12th Result to be announced today at 10:30 AM
- BSEB (biharboard.ac.in & biharboard.bih.nic.in): Bihar board 12th Arts result to be declared tomorrow on May 30