Diet may `reverse kidney failure` in diabetics

Last Updated: Monday, April 25, 2011 - 00:00

Diet may `reverse kidney failure` in diabetics
London: A controlled diet high in fat and
low in carbohydrate may help repair kidney damage in
diabetics, a new study has found.

Researchers at the Mount Sinai School of Medicine in New
York found a "ketogenic diet" could reverse the damage caused
to tubes in the kidneys by too much sugar in the blood.

For their study, the researchers used laboratory mice
with both type 1 and type 2 diabetes.

Once kidney damage had developed, half the mice were put
onto the ketogenic diet, which is 87 percent fat and mimics
the effect of starvation.

After eight weeks, the researchers noted that kidney
damage was reversed in those rodents which were on the highly
controlled diet, the leading news channel reported.

Professor Charles Mobbs, who led the research at Mount
Sinai School of Medicine, said: "Our study is the first to
show that a dietary intervention alone is enough to reverse
this serious complication of diabetes."

Though the findings have raised hope for people suffering
from diabetes, the scientists insisted that more research is
needed to ascertain whether such a diet would yield same
benefits for humans too.

"I certainly think it has promise, but I can`t recommend
it until we have done clinical trials," Professor Mobbs said.

The researchers also need to figure out the exact process
that leads to repair, he added.

Dr Iain Frame, director of research at Diabetes UK, said:
"This research was carried out in mice so it is difficult to
see how these results would translate into any real benefits
for people with diabetes at this stage.

"It is too simple to say that kidney failure could be
prevented by diet alone and it is also questionable whether
the diet used in this model would be sustainable for humans,
even in the short term."

Helen Nickerson, from the Juvenile Diabetes Research
Foundation, which part funded the research, said: "Dr Mobbs`
novel observation could lead to new molecular insights in
diabetic kidney disease."

The study was published in journal PLoS ONE.

PTI



First Published: Monday, April 25, 2011 - 00:00

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