Discovery of `quadruple helix` DNA in human cells promises new therapies for cancer
London: Cambridge researchers including an Indian origin have revealed that four-stranded `quadruple helix` DNA structures - known as G-quadruplexes - also exist within the human genome.
They form in regions of DNA that are rich in the building block guanine, usually abbreviated to `G`.
The findings mark the culmination of over 10 years investigation by scientists to show these complex structures in vivo - in living human cells - working from the hypothetical, through computational modelling to synthetic lab experiments and finally the identification in human cancer cells using fluorescent biomarkers.
The research goes on to show clear links between concentrations of four-stranded quadruplexes and the process of DNA replication, which is pivotal to cell division and production.
By targeting quadruplexes with synthetic molecules that trap and contain these DNA structures - preventing cells from replicating their DNA and consequently blocking cell division - scientists believe it may be possible to halt the runaway cell proliferation at the root of cancer.
"We are seeing links between trapping the quadruplexes with molecules and the ability to stop cells dividing, which is hugely exciting," said Professor Shankar Balasubramanian from the University of Cambridge`s Department of Chemistry and Cambridge Research Institute, whose group produced the research.
"The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells. For us, it strongly supports a new paradigm to be investigated - using these four-stranded structures as targets for personalised treatments in the future," he noted.
Physical studies over the last couple of decades had shown that quadruplex DNA can form in vitro - in the `test tube`, but the structure was considered to be a curiosity rather than a feature found in nature. The researchers now know for the first time that they actually form in the DNA of human cells.
"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer - the next part of this pipeline is to figure out how to target them in tumour cells," said Dr Julie Sharp, senior science information manager at Cancer Research UK.
The study led by Giulia Biffi, a researcher in Balasubramaninan`s lab at the Cambridge Research Institute, was published in Nature Chemistry.
More from India
More from World
More from Sports
More from Entertaiment
- Over 60 cadets killed in Pakistan police academy attack
- Panel discussion over vote bank politics on Hinduism
- DNA: Terrorists' new strategy of snatching weapons from Indian security personnel
- Watch: PM Narendra Modi's ''progressive'' remark on triple talaq
- Panel discussion over delayed development in Ayodhya
- Explosion in Delhi's Naya Bazar, one killed; anti-terror wing, Special cell at spot
- WATCH: Akhilesh Yadav's emotional speech revealing the real reason behind Samajwadi Party crisis; he was about to cry
- India vs New Zealand: Awestruck Kiwis witness MS Dhoni driving his Hummer in Ranchi, and photo goes viral
- Lashkar-e-Toiba claims responsibility for Uri attack in posters pasted in Pakistan town
- Naya Bazar explosion: Home Ministry seeks report from Delhi Police; one dead, 5 injured