Washington: Researchers have revealed new avenues to develop assessment tools and alternative treatments for people living with hereditary colorectal cancers.
The protein MutL – a matchmaker protein –recruits other enzymes and proteins within the cell to recognize, remove and correct mismatched DNA. "People with defective mismatch repair genes develop cancers at very early ages. You would see a family that in their 30s has colorectal cancer and in their 40s they have it again. “There``s no way you can prevent that – you can``t correct your DNA. As you grow older, you``re going to accumulate mutations," said Guarne. The results provide new avenues to develop alternative cancer treatments as the hope is future cancer therapies may be focused at the molecular level and involve blocking specific pathways within the cell.
The finding is published in the journal Molecular Cell. ANI
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