Washington: Researchers at Children’s Hospital Boston have created blood vessels from genetically engineered cells that could secrete drug on demand directly into the bloodstream to combat anaemia.Patients who rely on recombinant, protein-based drugs must often endure frequent injections, often several times a week, or intravenous therapy.They have reversed anaemia in mice with engineered vessels secreting erythropoietin (EPO). The technology could potentially be used to deliver other proteins such as Factor VIII and Factor IX for patients with hemophilia, alpha interferon for hepatitis C and interferon beta for multiple sclerosis, said the study’s principal investigator, Juan Melero-Martin, PhD, of the Department of Cardiac Surgery at Children’s. Such drugs are currently made in bioreactors by engineered cells, and are very expensive to make in large amounts.
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