Washington: Researchers have revealed that a recently discovered compound may have the potential to become part of a single-dose cure and also be able to block transmission of the parasite from person to person.
The compound from the aminopyridine class, code named MMV390048, shows potent activity against multiple points in the malaria parasite’s lifecycle.
On this basis it was selected by MMV’s ESAC for further development – making it the first compound researched on African soil to enter preclinical development in partnership with MMV.
The aminopyridine series was initially identified by Griffith University scientists in Australia as part of MMV’s extensive malaria screening campaign of around 6 million compounds.
A team of scientists from the University of Cape Town’s (UCT) Drug Discovery and Development Centre (H3-D) in South Africa, led by Prof. Kelly Chibale then scrutinised and explored the anti-malarial potential of the series further.
With parasitological and pharmacological support from the Swiss Tropical and Public Health Institute and Monash University, respectively, Kelly’s team selected the most promising compounds from the series to be optimized and re-tested.
In just 18 months the team had identified and developed a candidate suitable for preclinical development.
“We are very excited that this promising compound, researched by African scientists, has been selected by MMV for further development,” Prof. Kelly Chibale, Founder and Director, UCT H3-D, said.
“This is truly a proud day for African science and African scientists! Our team is hopeful that the compound will emerge from rigorous testing as an extremely effective medicine for malaria – a disease that accounts for 24 percent of total child deaths in sub-Saharan Africa,” Chibale said.
The findings of the study were presented at the MMV Expert Scientific Advisory Committee (ESAC) meeting in Toulouse, France.