Washington: A class of pharmaceuticals can both prevent and treat Alzheimer`s disease in mice, researchers at University of Southern California have found.The drugs, known as "TSPO ligands," are currently used for certain types of neuroimaging."We looked at the effects of TSPO ligand in young adult mice when pathology was at an early stage, and in aged mice when pathology was quite severe," said lead researcher Christian Pike of the USC Davis School of Gerontology."TSPO ligand reduced measures of pathology and improved behavior at both ages," Pike added.The most surprising finding for Pike and his team was the effect of TSPO ligand in the aged mice. Four treatments-once per week over four weeks-in older mice resulted in a significant decrease of Alzheimer`s-related symptoms and improvements in memory - meaning that TSPO ligands may actually reverse some elements of Alzheimer`s disease.
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