London:Researchers have discovered variant of an enzyme that can activate genes responsible for tumour progressions of colorectal cancer.Researchers from the IMIM (Hospital del Mar Medical Research Institute) believe that a new line of drugs to inhibit enzyme IKK alpha specifically which is less toxic for the remaining body cells can improve treatment of colorectal cancer."We studied the particularities that distinguish the pre-tumour activity of IKK alpha from its normal physiological activities, which are known to be essential for the survival of non-cancerous cells and can therefore not be pharmacologically inhibited without causing great harm to the body," said Dr Lluis Espinosa, director of the study.IKK alpha is a specific type of enzyme, known as kinase. These enzymes are proteins that act on other proteins adding to them a phosphate and thus modifying their function.
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