Faulty ‘wiring’ in the brain turns schizophrenia
Washington: A new study, conducted by researchers at the Institute of Psychiatry (IoP), King`s College London, suggests that abnormalities in the white matter of the brain appear to influence the development of schizophrenia.
The white matter of the brain consists of nerve fibres that connect parts of the brain and help regulate behaviour.
The normal brain develops in a back to front fashion, i.e. posterior regions mature first and the frontal lobes last.
Study authors Professor Phillip McGuire and Dr Sophia Frangou discovered that if there are very severe deficits in the white matter in these posterior (specifically parietal) regions, then schizophrenia develops early in adolescence.
As people grow older their deficits "migrate" in a back to front manner and in adulthood, they impact the frontal lobes of the brain quite dramatically.
“Although we can trace the origins of schizophrenia to early brain development we still do not know what triggers the onset of the full blown symptoms. Our study suggests that at least part of the answer lies in problems affecting the "wiring" of key brain areas,” McGuire said.
The team used Diffusion Tensor Imaging, a state-of-the-art neuro-imaging technique, to examine white matter connections in adolescents and adults with schizophrenia.
Abnormalities in white matter appeared first in posterior parts of the brain in the younger patients and became more prominent in the frontal lobes in adult patients.
In interpreting the results, Dr Kyriakopoulos, the lead author, explained that the scans capture the interaction between brain development and disease mechanisms.
Dr Frangou on the value of this research: “We believe this study is unique as it approaches schizophrenia research from a new perspective. It takes a life-long view on schizophrenia and thereby bridges traditional barriers between child and adult patients.”
The study adds new insight to mounting evidence that abnormalities in white matter play a critical role in what turns schizophrenia on and may provide clues to new treatments.
More from India
More from World
More from Sports
More from Entertaiment
- Revealed - How Indian Army hit terror camps across LoC!
- Pak forces will teach Zee News what real surgical strike is: Hafiz Saeed
- India used 'Cartosat 2c' satellite in surgical strikes against Pakistan
- Panel discussion on Hafiz Saeed's reaction after Indian Army surgical strikes
- DNA: Inside story of Indian Army's surgical strikes across LoC
- Hafiz Saeed threatens Zee News, says Pak forces will teach what real surgical strikes are
- Pak postpones SAARC Summit after five member states pull out of conference: As it happened
- After threatening Zee News, Hafiz Saeed says PM Modi, Ajit Doval staged `surgical strike drama'
- India's surgical strikes: Pakistan buries slain terrorists to hide evidence, asks Masood Azhar to go mum
- Who is Chandu Babulal Chauhan and why India wants to bring him back from Pakistan - Read