First Dengue vaccine shows moderate improvement in phase 3 trial
Washington: The first dengue vaccine candidate (CYD-TDV) has shown moderate protection (56 percent) against the disease in Asian children in phase 3 clinical testing, according to a new research.
The vaccine also showed 88.5 percent efficacy after 3 doses against severe disease (dengue haemorrhagic fever) which leads to hospitalisation for over half a million people (mostly children) every year, and 67 percent against dengue-associated hospitalisation.
Dr Maria Rosario Capeding, lead author from the Research Institute for Tropical Medicine in the Philippines, said that their results suggest that vaccination with CYD-TDV could reduce the incidence of symptomatic dengue infection by more than half and importantly reduced severe disease and hospitalisations. This candidate vaccine had the potential to have a significant impact on public health in view of the high disease burden in endemic countries.
Professor Annelies Wilder-Smith from Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore said that perhaps the most interesting finding of this trial was that efficacy after at least one dose was almost as high as that after three dose because three doses 6 months apart was an inconvenient and costly immunisation schedule for scale up in national programmes, the question of whether sufficient efficacy could be achieved with a lower number of doses deserves further assessment.
Smith added that for the moment, the CYD-TDV vaccine was the best they had, however, with 56percent efficacy it would never be a single solution.
The study is published in The Lancet.
Download the all new Zee News app for Android and iOS to stay up to date with latest headlines and news stories in Politics, Entertainment, Sports, Technology, Business and much more from India and around the world.
More from India
More from World
More from Sports
More from Entertaiment
- Delhi police arrests BSF personnel, ISI operative for espionage
- What is the motive behind 'unconditional talks' offer by Pakistan?
- Special report: Kashmiri Pandits recall their plight
- Jhansi's ammunition factory was target of ISI agents
- Panel discussion on film director Ali Akbar's accusation on Madrasa
- Video: India won't tolerate disrespect to national anthem – this Mumbai family learnt it the hard way
- Watch: Boy dies after falling from a Mumbai local train – video maker is guilty too!
- Had Sardar Patel become PM, India would have been another Pakistan, says Kancha Ilaiah
- Shocking! World Cup winning cricketer forced to sell 'kachoris' to make a living
- Watch: ISIS terrorist blown into pieces while bragging about his previous victory