Washington: Being exposed to estrogen over a long period of time is one factor that can increase a woman`s risk of developing breast cancer. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids—abundant in fish—could be a safe and beneficial booster for tamoxifen therapy. To investigate how fish oil intensifies the effects of tamoxifen, Jose Russo, director of the Breast Cancer Research Laboratory at Fox Chase, in collaboration with a team led by Andrea Manni, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks.
More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women. The new findings have been presented at the AACR 102nd Annual Meeting 2011 on Wednesday, April 6. ANI
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