Washington: In a new study, researchers found that exposing pregnant mice to low doses of the chemical tributyltin, which is used in marine hull paint and PVC plastic, can lead to obesity for multiple generations without subsequent exposure.After exposing pregnant mice to TBT in concentrations similar to those found in the environment, researchers from UC Irvine saw increased body fat, liver fat and fat-specific gene expression in their "children," "grandchildren" and "great-grandchildren" - none of which had been exposed to the chemical.These findings suggest that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects of fat accumulation without further exposure, said study leader Bruce Blumberg, UC Irvine professor of pharmaceutical sciences and developmental and cell biology.These effects appear to be inherited without DNA mutations occurring.
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