Frozen embryos boost IVF success

London: Use of frozen embryos is more likely to produce successful, complication-free IVF pregnancies than those that are fresh, a study has found.

A systematic review of more than 37,000 IVF pregnancies showed that there was a reduced chance of mothers bleeding and of babies being born prematurely with low birth weight when the embryos were stored and frozen compared with treatment involving freshly-transplanted ones, the Independent reported.

The review of 11 international studies also found that the death rate immediately before and after birth was lower in babies who were born as a result of transferring frozen-thawed embryos into the womb compared with the transfer of fresh IVF embryos.

The findings represent a “major paradigm change” in assisted reproduction and could lead to a change in the current policy of preferring fresh embryos to frozen ones, scientists said.

“If pregnancy rates are equal and outcome in pregnancies are better, our results question whether one should consider freezing all embryos and transferring them at a later date, rather than transferring fresh embryos,” said Abha Maheshwari, a lecturer at the University of Aberdeen who led the study published in Fertility and Sterility.

“This represents a major paradigm change in assisted reproduction, and one which could satisfy the twin demands of optimising safety and success. Traditionally it has been thought that fresh is always better and used as a first choice.

“Initially there were concerns about the safety of freezing techniques, and it was felt the quality of the embryo could deteriorate and impact on the health of the child. However, data to date has been reassuring,” he told the British Science Festival in Aberdeen.

Freezing embryos has become more popular since single embryos have been transferred, rather than the riskier transfer of two or more embryos.


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