Gene linked to deadly breast cancer found
Washington: Scientists from Weill Cornell Medical College and Houston Methodist have found that a gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of the triple negative form of the disease.
Their research suggests that targeting the gene may be a new approach to treating the disease.
About 42,000 new cases of triple negative breast cancer (TNBC) are diagnosed in the United States each year, about 20 percent of all breast cancer diagnoses. Patients typically relapse within one to three years of being treated.
Senior author Dr. Laurie H. Glimcher, the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College, wanted to know whether the gene - already understood from her prior work to be a critical regulator of immune and metabolic functions - was important to cancer's ability to adapt and thrive in the oxygen- and nutrient-deprived environments inside of tumors.
Using cells taken from patients' tumors and transplanted into mice, Dr. Glimcher's team found that the gene, XBP1, is especially active in triple negative breast cancer , particularly in the progression of malignant cells and their resurgence after treatment.
"Patients with the triple negative form of breast cancer are those who most desperately need new approaches to treat their disease," Dr. Glimcher, who is also a professor of medicine at Weill Cornell said.
"This pathway was activated in about two-thirds of patients with this type of breast cancer. Now that we better understand how this gene helps tumors proliferate and then return after a patient's initial treatment, we believe we can develop more effective therapies to shrink their growth and delay relapse," the researcher added.
The study is published in the journal Nature.
More from India
More from World
More from Sports
More from Entertaiment
- UP: Jammu-bound Muri Express derails in Kaushambi
- Five unmanned parachute-like objects spotted over Mumbai airport
- Aapke Sitare: Astro prediction for May 24, 2015
- Watch: Fast N Facts @ 7:30pm
- CBSE Board Class 12th Exam Results 2015 declared
- Jaipur girl Mini Rajpal wins Miss India Deaf 2015!
- Dawood's intercepted phone calls prove yet again he is in Pakistan
- One year of Modi govt: How satisfied is the common man?
- Delhi's 2015 CBSE Class 12 topper M Gayatri talks to Zee Media
- Mumbai architecture creates double decker bus from scrap!
- One year of Modi govt: How satisfied is the common man? Part-2
- One year of Modi govt: PM addresses mega rally in Mathura
- No respite from heat for next three days: IMD
- Growing medical negligence in Delhi's AIIMS
- Police registers case after parachute-like objects were spotted over Mumbai airport
- CBSE.nic.in 12th XII Results 2015: CBSE Board (cbseresults.nic.in) Class 12th XII Exam Results 2015 to be announced on May 25
- Heatwave claims over 550 lives so far, Delhi saw hottest day
- LIVE - Cbse.nic.in & cbseresults.nic.in Class 12th XII Results 2015: CBSE Board Class 12th XII Exam Results 2015 to be announced shortly
- Cbse.nic.in & cbseresults.nic.in Class 12th XII Results 2015: CBSE Board Class 12th XII Exam Results 2015 declared
- IPL 2015 final: Mumbai Indians thrash Chennai Super Kings by 41 runs to lift second title
- Check cbseresults.nic.in for CBSE Class 12 result 2015
- Two dead, over 100 injured as Muri Express derails in UP; Prabhu announces Rs 2 lakhs ex-gratia for kin of dead
- Mathura rally: PM Modi slams 'corrupt' UPA regime, lauds NDA govt's efforts in past one year
- Check WBBSE (wbresults.nic.in) Class 12th Results: West Bengal Board (wbscvet.org) Higher Secondary Class XII Vocational Results to be declared today at 4 PM
- PM Narendra Modi's Mathura rally: As it happened
- CBSE Class 12 results out: Here's how you can check
- Public rally on 100 days of AAP govt: As it happened
- CBSE Board 12th XII Results 2015: Cbse.nic.in & cbseresults.nic.in Class 12th XII Exam Results 2015 to be announced today at 12 Noon
- Kejriwal lists AAP govt's achievements of 100 days, slams Centre's 'dictatorial attitude'
- Arvind Kejriwal's Aam Aadmi Party changes its logo