Gene vital to central nervous system development found
Scientists have identified a gene that helps regulate how well nerves of the central nervous system are insulated.
New York: Scientists have identified a gene that helps regulate how well nerves of the central nervous system are insulated.
Healthy insulation is vital for the speedy propagation of nerve cell signals.
The finding, in zebrafish and mice, may have implications for human diseases like multiple sclerosis in which this insulation is lost.
The researchers from Washington University's school of medicine in St Louis focused on a gene called Gpr56 which manufactures a protein of the same name.
Previous work indicated that this gene was likely to be involved in central nervous system development but its specific roles were unclear.
In the new study, they found that without Gpr56, the cells responsible for applying the insulation failed to reproduce themselves sufficiently.
"These cells actually matured too early instead of continuing to replicate as they should have. Consequently, in adulthood, there were not enough mature cells, leaving many axons without insulation," said study's senior author Kelly R. Monk, assistant professor of developmental biology.
Nerve cells send electrical signals along lengthy projections called axons.
These signals travel much faster when the axon is wrapped in myelin, an insulating layer of fats and proteins.
Gpr56 belongs to a large class of cell receptors that are common targets for many commercially available drugs, making the protein attractive for further research.
The investigators pointed out its possible relevance in treating diseases associated with a lack of myelin, with particular interest in multiple sclerosis.
The study appeared in the journal Nature Communications.