Washington: A study has indicated that the genes we possess not only determine the color of our eyes and hair and how our bodies grow, but they might also influence the changes that occur in tumors when we develop cancer. A study by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) suggests that our normal genetic background – the genetic variations that we inherit – contributes to the kinds of DNA changes that occur in tumor cells as cancer develops. The researchers compared multiple independent tumors from people with a form of skin cancer called squamous cell carcinoma (SCC) for losses and gains of DNA in tumor cells. They found that the pattern of these changes is quite similar in tumors from the same person but quite different in tumors from different individuals. The findings may offer a new way to identify individuals at greater risk for developing cancer, the researchers say.
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