Genes that keep watch on blood clotting time found

Last Updated: Tuesday, March 23, 2010 - 00:00

Washington: Researchers at the University of Edinburgh have discovered three genes that could shed light on the genetic causes of blood-clotting disorders such as thrombosis and some types of stroke.

The boffins discovered that the three genes make a substantial contribution to how long it takes blood to clot.

The team thinks that identifying these genes that control the way blood clots could help further our understanding of conditions such as deep vein thrombosis, heart attacks, some types of stroke, and bleeding disorders.

The study was carried out at the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), part of the cross council Lifelong Health and Wellbeing Initiative.

The study looked for associations between half a million genetic markers and time taken for blood to clot, measured by a test called activated partial thromboplastin time (aPTT).

The findings show three genes - called F12, HRG and KNG1 - are responsible for a substantial amount of the variation in speed of blood clotting in different healthy people.

The team will now try to encourage research teams working on relevant medical disorders to study these genes.

Dr Lorna Houlihan, from the University of Edinburgh performed the analysis with help from experts in Edinburgh, Glasgow, and Brisbane She said, "This is an exciting genetic discovery, especially as so few genes account for such a large effect. We have explored the genetics of the medical information that has been given by our cohorts of older people. When I saw this huge finding on the genetics of blood clotting I first checked that it occurred in both our groups - it did. Then I checked that no-one else had discovered this - they hadn``t. Then the team set about establishing the possible medical implications for some blood disorders."

The results are published in the American Journal of Human Genetics.

ANI



First Published: Tuesday, March 23, 2010 - 00:00

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