Washington: Scientists have cracked the genetic code of a sudden death cardiac killer.
The excitement among cardiologists concerns a rare genetic condition – arrhythmogenic right ventricular cardiomyopathy (ARVC). "Newfoundlanders likely have the highest incidence in the world of this disease," Dr. Connors, a cardiologist and associate professor of medicine at Memorial University in Newfoundland, told the Congress. The term arrhythmogenic refers to deadly cardiac rhythms that can be triggered by electrical impulses within the heart. Cardiomyopathy is a worsening condition where heart muscle is slowly replaced by scar and fat tissue.The combination of the two is lethal, Dr. Connors says."People who are at risk often have no symptoms, so the first time we know they have this disease is when they die."The surest sign that a disease is genetic in origin is when it is manifests itself in family histories, showing up in generation after generation."Our diagnostic testing showed that some members of these families have a specific, genetic, electrocardiogram (ECG) mutation – ARVD5," said Dr. Connors.There is a 50 per cent chance that children of those with the condition will also be carriers of the gene. It is considered the second-most common cause of sudden cardiac death in young people.The mutation causes premature sudden cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50 years. For women the rate is five per cent and 20 per cent.Given those figures, Dr. Connors realized nothing would be lost by implanting ICDs in asymptomatic patients with ARVD5 to maintain normal heart rhythms. ANI
Will write my own book to tell the truth: Sonia
India, America `indispensable partners`: John Kerry
Hrithik upset with Rs 400 cr alimony rumours
Eating chicken could make you immune to antibiotics