Washington: A statistical model that accounts for different genes in combination - and the interactions between them - is an important step in understanding the genetic factors that affect the risk of acquiring Crohn`s disease.According to the study by a research group from the Cleveland Clinic and University of Pittsburgh, it`s not just how many risk genes are present but how those genes interact with each other that determines the inheritance of Crohn`s disease (CD) risk.The exact cause for the disease is unknown, but Crohn`s disease appears to result from an `inappropriate persistent immune response.`In addition to genetics, microbial and environmental factors likely play important roles in the development of CD.To address this issue, the researchers developed a new model exploring `higher-order genetic interactions` among known CD risk genes. The model was designed to evaluate not only the additive effects of having multiple CD risk genes, but also the possible impact of interactions between genes.
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