Washington: Innovative studies have explored a number of promising pathways for treatment and new targets for preventing the spread of breast cancer.In these studies, a multidisciplinary approach was applied to analyse the molecular basis of breast cancer bone metastasis, combining tools to analyse genomic information with animal models and clinical analysis of cancer metastasis. Candidate genes, including one dependent on EGFR 3 (Epidermal Growth Factor Receptor), and a TGFb (Transforming Growth Factor-beta) target gene called Jagged1 were identified. The study revealed a network of molecular crosstalk between tumour and bone cells using Jagged1 in tumour cells, EGFR in bone cells and TGFb released from damaged bone. Such pathological tumour-host tissue interactions eventually lead to tumour expansion and bone destructions.
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